Doseringen bij gestoorde nierfunctie
Uit Richtlijnen HIV
(Verschil tussen bewerkingen)
Regel 1: | Regel 1: | ||
{| width="100%" border="1" cellpadding="1" cellspacing="1" | {| width="100%" border="1" cellpadding="1" cellspacing="1" | ||
|- | |- | ||
- | | rowspan="2" | | + | | rowspan="2" | G'''eneesmiddel<br>''' |
- | | rowspan="2" | Normale dosis<br> | + | | rowspan="2" | '''Normale dosis<br>''' |
- | | colspan="3" | eGFR | + | | colspan="3" | '''eGFR''' |
- | | rowspan="2" | Wordt middel verwijderd | + | | rowspan="2" | |
+ | '''Wordt middel '''<br>'''verwijderd <br>door dialyse?''' | ||
+ | |||
|- | |- | ||
| | | | ||
- | CLcr<br>30-50 ml/min | + | '''CLcr<br>30-50 ml/min''' |
- | | CLcr<br>10-30 ml/min | + | | '''CLcr<br>10-30 ml/min''' |
- | | CLcr<br><10 ml/min | + | | '''CLcr<br><10 ml/min''' |
|- | |- | ||
- | | Zidovudine | + | | Zidovudine |
- | | 300 mg 2dd | + | | 300 mg 2dd |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
- | | 300 mg 1dd | + | | 300 mg 1dd |
| Ja | | Ja | ||
|- | |- | ||
- | | Didanosine | + | | Didanosine |
- | | 400 mg 1dd | + | | 400 mg 1dd |
- | | 200 mg 1dd | + | | 200 mg 1dd |
- | | 125 mg 1dd | + | | 125 mg 1dd |
- | | 125 mg 1dd | + | | 125 mg 1dd |
| Ja | | Ja | ||
|- | |- | ||
- | | Stavudine | + | | Stavudine |
- | | 40 mg 2dd | + | | 40 mg 2dd |
- | | 20 mg 2dd | + | | 20 mg 2dd |
- | | 20 mg 1dd | + | | 20 mg 1dd |
- | | 20 mg 1dd | + | | 20 mg 1dd |
| Ja | | Ja | ||
|- | |- | ||
- | | Lamivudine | + | | Lamivudine |
- | | 300 mg 1dd | + | | 300 mg 1dd |
- | | 150 mg 1dd | + | | 150 mg 1dd |
- | | 50-100 mg 1dd | + | | 50-100 mg 1dd |
- | | 25-50 mg 1dd | + | | 25-50 mg 1dd |
| Ja | | Ja | ||
|- | |- | ||
- | | Abacavir | + | | Abacavir |
- | | 600 mg 1dd | + | | 600 mg 1dd |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
| Ja | | Ja | ||
|- | |- | ||
- | | Tenofovir DF | + | | Tenofovir DF |
- | | 245 mg 1dd | + | | 245 mg 1dd |
- | | 245 mg Q48h | + | | 245 mg Q48h |
- | | 245 mg Q72-96h | + | | 245 mg Q72-96h |
- | | 245 mg Q7dagen | + | | 245 mg Q7dagen |
| Ja | | Ja | ||
|- | |- | ||
- | | Tenofovir AF | + | | Tenofovir AF |
- | | 25 mg 1dd | + | | 25 mg 1dd |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
- | | CI | + | | CI |
| Ja | | Ja | ||
|- | |- | ||
- | | Emtricitabine | + | | Emtricitabine |
- | | 200 mg 1dd | + | | 200 mg 1dd |
- | | 200 mg Q48h | + | | 200 mg Q48h |
- | | 200 mg Q72h | + | | 200 mg Q72h |
- | | 200 mg Q96h | + | | 200 mg Q96h |
| Ja | | Ja | ||
|- | |- | ||
- | | Saquinavir/r | + | | Saquinavir/r |
- | | 1000/100 mg 2dd | + | | 1000/100 mg 2dd |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
| Nee | | Nee | ||
|- | |- | ||
- | | Indinavir/r | + | | Indinavir/r |
- | | 800/100 mg 2dd | + | | 800/100 mg 2dd |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
| Ja | | Ja | ||
|- | |- | ||
- | | Lopinavir/r | + | | Lopinavir/r |
- | | 400/100 mg 2dd | + | | 400/100 mg 2dd |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
| Nee | | Nee | ||
|- | |- | ||
- | | Forsamprenavir/r | + | | Forsamprenavir/r |
- | | 1400/200 mg 1dd of 700/100 mg 2dd | + | | 1400/200 mg 1dd of 700/100 mg 2dd |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
| Nee | | Nee | ||
|- | |- | ||
- | | Atazanavir/r | + | | Atazanavir/r |
- | | 300/100 mg 1dd | + | | 300/100 mg 1dd |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
| Nee | | Nee | ||
|- | |- | ||
- | | Atazanavir/c | + | | Atazanavir/c |
- | | 300/150 mg 1dd | + | | 300/150 mg 1dd |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
| Nee | | Nee | ||
|- | |- | ||
- | | Tipranavir/r | + | | Tipranavir/r |
- | | 500/200 mg 2dd | + | | 500/200 mg 2dd |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
| Nee | | Nee | ||
|- | |- | ||
- | | Darunavir/r | + | | Darunavir/r |
- | | 800/100 mg 1dd | + | | 800/100 mg 1dd |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
| Nee | | Nee | ||
|- | |- | ||
- | | Darunavir/c | + | | Darunavir/c |
- | | 800/150 mg 1dd | + | | 800/150 mg 1dd |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
| Nee | | Nee | ||
|- | |- | ||
- | | Nevirapine | + | | Nevirapine |
- | | 400 mg 1dd | + | | 400 mg 1dd |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
| Ja | | Ja | ||
|- | |- | ||
- | | Efavirenz | + | | Efavirenz |
- | | 600 mg 1dd | + | | 600 mg 1dd |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
| Nee | | Nee | ||
|- | |- | ||
- | | Etravirine | + | | Etravirine |
- | | 200 mg 2dd | + | | 200 mg 2dd |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
| Nee | | Nee | ||
|- | |- | ||
- | | Rilvipirine<sup>2</sup> | + | | Rilvipirine<sup>2</sup> |
- | | 25 mg 1dd | + | | 25 mg 1dd |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
| Nee | | Nee | ||
|- | |- | ||
- | | Raltegravir | + | | Raltegravir |
- | | 400 mg 2dd | + | | 400 mg 2dd |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
| Nee | | Nee | ||
|- | |- | ||
- | | Elvitegravir/c | + | | Elvitegravir/c |
- | | 125/150 mg 1dd | + | | 125/150 mg 1dd |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
| Nee | | Nee | ||
|- | |- | ||
- | | Dolutegravir<sup>2</sup> | + | | Dolutegravir<sup>2</sup> |
- | | 50 mg 1dd | + | | 50 mg 1dd |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
| Nee | | Nee | ||
|- | |- | ||
- | | Maraviroc | + | | Maraviroc |
- | | 300 mg 2dd | + | | 300 mg 2dd |
- | | Normaal | + | | Normaal |
- | | Normaal<sup>1</sup> | + | | Normaal<sup>1</sup> |
- | | Normaal<sup>1</sup> | + | | Normaal<sup>1</sup> |
| Ja | | Ja | ||
|- | |- | ||
- | | Enfuvirtide | + | | Enfuvirtide |
- | | 90 mg 2dd | + | | 90 mg 2dd |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
- | | Normaal | + | | Normaal |
| Nee | | Nee | ||
|} | |} |
Versie op 27 aug 2017 10:03
Geneesmiddel | Normale dosis | eGFR |
Wordt middel | ||
CLcr | CLcr 10-30 ml/min | CLcr <10 ml/min | |||
Zidovudine | 300 mg 2dd | Normaal | Normaal | 300 mg 1dd | Ja |
Didanosine | 400 mg 1dd | 200 mg 1dd | 125 mg 1dd | 125 mg 1dd | Ja |
Stavudine | 40 mg 2dd | 20 mg 2dd | 20 mg 1dd | 20 mg 1dd | Ja |
Lamivudine | 300 mg 1dd | 150 mg 1dd | 50-100 mg 1dd | 25-50 mg 1dd | Ja |
Abacavir | 600 mg 1dd | Normaal | Normaal | Normaal | Ja |
Tenofovir DF | 245 mg 1dd | 245 mg Q48h | 245 mg Q72-96h | 245 mg Q7dagen | Ja |
Tenofovir AF | 25 mg 1dd | Normaal | Normaal | CI | Ja |
Emtricitabine | 200 mg 1dd | 200 mg Q48h | 200 mg Q72h | 200 mg Q96h | Ja |
Saquinavir/r | 1000/100 mg 2dd | Normaal | Normaal | Normaal | Nee |
Indinavir/r | 800/100 mg 2dd | Normaal | Normaal | Normaal | Ja |
Lopinavir/r | 400/100 mg 2dd | Normaal | Normaal | Normaal | Nee |
Forsamprenavir/r | 1400/200 mg 1dd of 700/100 mg 2dd | Normaal | Normaal | Normaal | Nee |
Atazanavir/r | 300/100 mg 1dd | Normaal | Normaal | Normaal | Nee |
Atazanavir/c | 300/150 mg 1dd | Normaal | Normaal | Normaal | Nee |
Tipranavir/r | 500/200 mg 2dd | Normaal | Normaal | Normaal | Nee |
Darunavir/r | 800/100 mg 1dd | Normaal | Normaal | Normaal | Nee |
Darunavir/c | 800/150 mg 1dd | Normaal | Normaal | Normaal | Nee |
Nevirapine | 400 mg 1dd | Normaal | Normaal | Normaal | Ja |
Efavirenz | 600 mg 1dd | Normaal | Normaal | Normaal | Nee |
Etravirine | 200 mg 2dd | Normaal | Normaal | Normaal | Nee |
Rilvipirine2 | 25 mg 1dd | Normaal | Normaal | Normaal | Nee |
Raltegravir | 400 mg 2dd | Normaal | Normaal | Normaal | Nee |
Elvitegravir/c | 125/150 mg 1dd | Normaal | Normaal | Normaal | Nee |
Dolutegravir2 | 50 mg 1dd | Normaal | Normaal | Normaal | Nee |
Maraviroc | 300 mg 2dd | Normaal | Normaal1 | Normaal1 | Ja |
Enfuvirtide | 90 mg 2dd | Normaal | Normaal | Normaal | Nee |